For formal publication, the results will be submitted to a peer-reviewed journal.
The study, documented under the identifier ACTRN12620001007921, is being returned.
We are returning the information associated with study ACTRN12620001007921.
To determine the frequency of hyperuricemia within a Finnish senior population, and to evaluate its connection with concurrent health conditions and death rates.
The research design involved a prospective cohort study.
A longitudinal study, titled 'Good Ageing in Lahti Region', spanning the years 2002 to 2012 in Finland, scrutinized mortality records until 2018.
Of the 2673 participants, 47% were male, and their average age was 64 years.
Hyperuricaemia levels were observed to be prevalent among the studied subjects. Hyperuricemia's association with mortality was analyzed via the application of multivariable-adjusted Cox proportional hazards models.
Utilizing data gathered from a population-based, prospective study of elderly individuals (52-76 years old) residing in the Lahti region of Finland. Serum uric acid (SUA) levels, alongside other laboratory variables, comorbidities, lifestyle habits, and socioeconomic factors, were documented, enabling an analysis of the association between SUA levels and mortality outcomes over a 15-year follow-up.
The research group comprised 2673 elderly Finnish people; within this group, 1197 (48%) presented with hyperuricemia. A significant prevalence of hyperuricemia was observed in men, reaching 60%. Elevated serum uric acid (SUA) and mortality rates demonstrated an association, a link that remained significant after accounting for possible confounding factors, including age, gender, education, smoking history, body mass index, hypertension, and dyslipidemia. Relative to normouricaemic individuals (SUA < 360 mol/L), women with hyperuricaemia (SUA 420 mol/L) demonstrated an adjusted hazard ratio of 1.32 (95% CI 1.05-1.60) for all-cause mortality. Men with similar hyperuricaemia exhibited a comparable adjusted hazard ratio of 1.29 (95% CI 1.05-1.60). For individuals experiencing a mild elevation in serum uric acid (SUA between 360 and 420 mol/L), the corresponding hazard ratios were 1.03 (95% confidence interval, 0.78 to 1.35) and 1.11 (95% confidence interval, 0.89 to 1.39).
Among the elderly Finnish population, hyperuricemia is significantly prevalent and independently linked to a higher risk of mortality.
Elevated uric acid levels, a prevalent issue amongst Finland's senior citizens, are independently associated with a greater risk of death.
Examining formal service use and help-seeking actions regarding violence among children in Zimbabwe, under the age of 18, is the goal of this study.
Our research uses cross-sectional data from the 2017 Zimbabwe Violence Against Children Survey (VACS), which was nationally representative, recording a 72% response rate amongst female participants and a 66% response rate among male participants. Furthermore, we utilize anonymized routine data from the call database of Childline Zimbabwe, a prominent child protection service provider.
Zimbabwe.
The 2017 VACS data, pertaining to individuals aged 13 to 18, was examined. Further analysis was conducted using data sourced from Childline Zimbabwe's call database, encompassing respondents who were 18 years of age or younger.
Using unadjusted and logistic regression models, we analyze child characteristics to understand their connection with help-seeking knowledge and behaviors.
A 2017 VACS survey in Zimbabwe, examining 4622 children aged 13 to 18 years, found that 1339 (298% of the sample) had a history of physical and/or sexual violence. liquid optical biopsy The survey revealed that 829 (573%) children lacked knowledge about formal assistance avenues, contrasting with 364 (331%) who possessed this awareness but did not utilize it, and 139 (96%) children effectively sought the assistance. Although boys generally knew more about places to find assistance, girls often made a greater effort to actively seek help from those sources. Lateral flow biosensor During the data collection period for the VACS survey, spanning six months, Childline registered a total of 2177 calls, where violence against individuals 18 years of age or under was the main reported issue. A greater concentration of reports regarding violence experienced by girls and children in school appeared in the 2177 calls, exceeding the typical incidence of violence against children nationwide. There were few children who did not solicit help and who expressed no wish for the services. Children who did not seek support often expressed feeling at fault or worried that disclosing the matter would put them at risk.
Gender impacts both service awareness and help-seeking, underscoring the need for separate strategies to help boys and girls access the support they require. Childline's outreach to boys and their better integration into the reporting process for school-based violence is crucial. Simultaneously, Childline should extend its support to children not currently in school.
Gender influences both awareness of services and help-seeking, implying that distinct approaches are necessary to encourage boys and girls to utilize the support they require. In order to effectively reach boys and receive more reports of school-related violence, Childline must consider efforts to engage with children who are outside of the school system, a crucial step.
Chronic conditions are becoming more prevalent, leading to multimorbidity and more complex care requirements. This burden on healthcare teams translates into unmet needs for patients and families, and a demanding workload for healthcare professionals. To address these difficulties, care models incorporating nurse practitioners were implemented. Even with the advantages already confirmed, the implementation in Belgium is still at an early stage of deployment. Evaluation of nurse practitioner roles in a Belgian university hospital is the aim of this study, which includes development and implementation. Healthcare managers and policymakers can draw upon insights from developmental and implementation processes for future (national) deployments.
To cultivate and evaluate nurse practitioner roles across three departments of a Belgian university hospital, a participatory action research framework will be implemented, involving interdisciplinary teams of healthcare professionals, managers, and researchers. A longitudinal (matched control) pre-post mixed-methods study will be implemented to assess the effectiveness of healthcare interventions at the patient (e.g., quality of care), healthcare provider (e.g., team effectiveness), and organizational level (e.g., utility). Data analysis of quantitative information, such as survey results, electronic patient data, and administrative files, will be performed using SPSS version 28.0. Data gathering for the qualitative aspects of the project will involve meetings, focus group discussions, and the recording of field observations throughout the entire process. Thematic analysis will be used for the analysis of all qualitative data, encompassing both the study of patterns across cases and within specific cases. This study is formatted and will be presented in accordance with the stipulations of the Standard Protocol Items Recommendations for Interventional Trials 2013.
Ethical approval for all components of this research was given by the Ethics Committee of the involved university hospital, effective throughout the period from February to August 2021. In all sections of the study, participants will receive written and verbal communication, and will be asked to provide written consent. All data is safely kept on a secure server. Primary researchers alone will have the privilege of accessing the data set.
NCT05520203.
NCT05520203.
Potentially enabling early intervention, prehospital detection of intracerebral hemorrhage (ICH) without conventional imaging may limit hematoma enlargement and enhance patient recovery. Although intracranial hemorrhage (ICH) and ischemic stroke share a range of clinical characteristics, specific signs can be helpful in correctly identifying ICH among suspected stroke patients. Advanced diagnostic technologies, combined with the clinical presentation, may ultimately enhance diagnosis. To conduct a scoping review, we intend to firstly pinpoint the early, distinctive clinical indicators of intracranial hemorrhage (ICH), and subsequently identify innovative, portable technologies that might bolster the differentiation of ICH from other suspected cerebrovascular conditions. Under conditions of appropriateness and practicality, meta-analyses are planned to be performed.
In accordance with the Joanna Briggs Institute Methodology for Scoping Reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist, the scoping review will proceed. With the use of MEDLINE (Ovid), EMBASE (Ovid), and CENTRAL (Ovid), a meticulous search process will be undertaken. By using EndNote's reference management software, duplicate entries will be removed. According to pre-specified eligibility criteria, two independent reviewers will screen titles, abstracts, and full-text reports, employing Rayyan Qatar Computing Research Institute software. All titles, abstracts, and full-text reports for potentially suitable studies will be evaluated by one reviewer, and a second reviewer will independently verify at least 20% of them. A discussion or referral to an external third-party reviewer will be the method used to settle any conflict. The scoping review's objectives will guide the tabulation of results, while a narrative discussion will complement these findings.
This review, utilizing only published literature, is not subject to ethical approval requirements. Peer-reviewed publication in an open-access journal, accompanied by presentations at scientific conferences, will be integrated into a PhD dissertation. B02 manufacturer Subsequent research into the early diagnosis of ICH in stroke patients is expected to incorporate the insights gleaned from these findings.
Because this review will draw only from published material, ethical clearance is not needed.